Resident Evil: Extinction (2007), the third installment in the franchise, takes place years after the catastrophic spread of the T-virus, which has ravaged Earth and turned much of humanity into zombies. The once-thriving cities have collapsed into ruins, and the world has become a barren wasteland. The Umbrella Corporation continues its experiments underground, trying to domesticate the infected and searching for a way to control Alice, their most dangerous creation.

Alice (Milla Jovovich), now wandering alone, has evolved with superhuman abilities due to Umbrella’s experiments on her. She eventually reunites with a convoy of survivors led by Claire Redfield (Ali Larter), Carlos Oliveira (Oded Fehr), and L.J. (Mike Epps). Together, they battle hordes of zombies, mutated crows infected by the virus, and relentless Umbrella forces.
As the group seeks a rumored safe haven in Alaska, Umbrella scientist Dr. Isaacs becomes obsessed with capturing Alice to harness her blood’s potential to reverse or control the virus. This obsession leads to a climactic showdown between Alice and a monstrous, mutated Isaacs inside an Umbrella facility.
The film ends with Alice discovering her clones, setting the stage for the war against Umbrella to escalate further.